John is a seven-year old boy living in the northeastern US with a long standing diagnosis of autism. Symptoms include temper tantrums, repetitive self-stimulatory behavior, impaired language, mood swings, fear of being alone, toileting problems, dysbacteriosis, and impaired muscle strength. John spends a lot of time outdoors starting in the spring and his mother noticed a distinct seasonal variation in his symptoms in that he improved in the summer and regressed in the winter. A 25-hydroxy-vitamin D in April of 2008 was 25 ng/ml and obtained after John had begun to play outside. Due to the seasonality of John's symptoms the mother consulted me and I advised the mother to stop all products containing vitamin A including cod liver oil and begin John on 5,000 IU of vitamin D3 per day for two weeks followed by 2,000 IU per day in the form of powdered vitamin D dissolved in juice. Within a week of starting the vitamin D language began to return and he was no longer as fearful of being alone. At the end of two weeks his language showed further improvement, he began to toilet himself, counted to 10 and knew the spelling of his name. After three weeks language continued to improve and some improvements were noted in his dysbiosis. After four weeks of vitamin D treatment, the mother noted improvements in muscle strength as well as continued improvements in language. A repeat 25-hydroxy-vitamin D is pending while John continues taking 2,000 IU of vitamin D per day.
Dear John: I apologize for the delay in getting back to you regarding VDR polymorphisms. Initial studies by Eisman and coworkers many years ago suggested that several of the polymorphs identified above in the VDR gene (Bsm/Tag) correlated strongly with osteoporosis. Despite the hoopla, subsequent analyses by many different investigators did not really confirm these results, i.e. only a very modest (3%) correlation. This spawned multiple studies searching forcorrelations between VDR polymorph's and cancer, autoimmune disease and so forth. It is fair to say from all of these studies that the correlation is atbest weak, and in most cases non-existent. Part of this may be due to the factthat the Bsm and Taq polymorphs are located in VDR gene introns and as a first approximation cannot affect the VDR protein's function. This is not an absolute statement, however, as our work is now showing that regulatory regions that control the VDR's expression are located within introns as well as upstream. Therefore the possibility exists that these polymorphs could affect expression, although we have not found these regions to contain enhancers yet. This is clearly where gene and disease studies are going. The only polymorph that could affect function is the Fok1 site, which we identified many years ago following our initial cloning and structuralanalysis of the human VDR gene. The presence of this site leads to the expression of a shorter VDR protein (424 aa)that is purported to have a slight increase in transcriptional activity (10%?) vs the large protein (427 aa). The above analysis suggests that this polymorphis absent, leading to production of the larger perhaps less active protein. On a single patient basis, it is really difficult to conclude anything regarding thisfinding. Indeed, despite large numbers of patients, the VDR polymorph have not really revealed any significant insight. Given the summer correlations, it is probably more likely that the individual is low in vitamin D3 in winter. Sincerely, Professor John Doe
The Vitamin D Council 9100 San Gregorio Road Atascadero, CA 93422
Equation # 1)--Radiation (spin polarization right-hand, in-phase, backward-in-time)--"Photon Holes" + Matter (spin polarization right-hand, in-phase, forward-in-time)--"Photon Holes" + Antimatter (spin polarization left-hand, out-of-phase, backward-in-time)--"Photons" + Radiation (spin polarization left-hand, out-of-phase, forward-in-time)--"Photons" = 0
Equation # 2)--Matter (spin polarization right-hand, in-phase, forward-in-time)---"Photon Holes" + Antimatter (spin polarization left-hand, out-of-phase, backward-in-time)---"Photons" = 0
If: A) Photon Holes + Photons = 0 And: B) Matter + Antimatter = 0 Then, by comparing # 1 and # 2---both items on left and on right: Photon Holes = Matter, And: Photons = Antimatter. So, charge may enter into this also by: C) A Charge + Its Opposite = 0
14C --> 14N + e- + 19Ne --> 19F + e+ +
Best line ever:Have fun in your ignorance believing what you choose, but I choose to be enlightened.
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Best line ever:
Have fun in your ignorance believing what you choose, but I choose to be enlightened.
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